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Structural modifications have been introduced and medical within the vertebrate lineage, for while homologs of the CYP11 family, responsible for the first step of synthesis for all steroids, are observed throughout vertebrata from fish to mammals (37, 38) (Figure 3), the CYP11B family, responsible for glucocorticoid and mineralocorticoid synthesis, is underrepresented throughout this subphylum (Figure. 1,026.
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